Estradiol (E2)
Men's/women's healthThe primary active estrogen in the body.
Estradiol is produced in the gonads (ovaries and testes) and in adipose tissue. It plays a central role in bone metabolism, cardiovascular protection, brain function, mood regulation, and reproductive health. Levels vary with the menstrual cycle and decline significantly during menopause. Low levels are associated with reduced bone density, mood disturbances, and impaired fertility. Elevated levels may indicate hormonal imbalance or increased aromatase activity.
Reference range
Source: Ahead Health benchmark
Reference ranges may vary between labs and assays. Always interpret results with your healthcare provider.
Why this matters
Low levels are associated with reduced bone density, mood disturbances, vasomotor symptoms (e.g. hot flashes), and impaired fertility.
Elevated levels may indicate hormonal imbalance, increased aromatase activity, or oestrogen-producing pathology. Monitoring supports assessment of reproductive function, menopausal status, and hormone therapy.
How this connects to other biomarkers
- Estradiol is produced from testosterone via aromatase. Interpret alongside SHBG (determines free estradiol availability), testosterone (substrate), and FSH/LH (pituitary feedback).
Ready to check your health?
Get a comprehensive view of your biomarkers with our advanced check-up packages.